Step on a bathroom scale and about 99% of what it reads is not the stuff you're made of.
By now we all know we're made of atoms, and that an atom contains protons, neutrons and electrons, and that protons in turn are made of quarks.
But weigh every quark and electron in your body separately, add them all up, and you'd get about 1% of the number on the scale.
The other 99% isn't material. It's energy: the motion and churn going on inside every proton in you, right now, constantly. A tiny part of our mass is made up of matters, but a majority, energy.
We have now proved it, but for a long time nobody could.